SSRIs, Akathisia and Suicide Risk

If you suffer from either of the following-  depression, obsessive-compulsive disorder, anxiety disorders, post-traumatic stress disorder (PTSD), and premenstrual dysphoric disorder (PMDD). you may be prescribed a drug called Paxil, an SSRI. All explanations follow.

Paxil is one of a class of antidepressant drugs known as selective serotonin reuptake inhibitors or SSRI’s.  These have become some of the most commonly prescribed drugs in America and worldwide, offered to treat a wide range of emotional ills from grief to social anxiety.   But while many people find them helpful, they have long been known to make some patients irritable and anxious. (Healy’s blog)

{PAXIL (paroxetine hydrochloride) is an orally administered psychotropic drug. It is the hydrochloride salt of a phenylpiperidine compound identified chemically as (-)-trans-4R-(4’fluorophenyl)-3S-[(3′,4′-methylenedioxyphenoxy) methyl] piperidine hydrochloride hemihydrate and has the empirical formula of C19H20FNO3•HCl•½H2O. The molecular weight is 374.8 (329.4 as free base). The structural formula of paroxetine hydrochloride is:

Paroxetine hydrochloride is an odorless, off-white powder, having a melting point range of 120° to 138°C and a solubility of 5.4 mg/mL in water.

This information is taken from- this link (please click it for more information)}

Common side effects

You can read effects of this medicine by clicking here.

However, the common ones are- asthenia, constipation, diarrhea, dizziness, drowsiness, ejaculatory disorder, erectile dysfunction, insomnia, male genital disease, nausea, headache, decreased libido, delayed ejaculation, diaphoresis, and xerostomia.

Other side effects include: infection, blurred vision, female genital tract disease, impotence, lack of concentration, orgasm disturbance, tremor, vasodilatation, visual disturbance, anxiety, paresthesia, abnormal dreams, decreased appetite, and yawning.

In India Paxil sells under the brand names- Cinpar, Oxitine PR, Leparox, Deprox,Onbixin, Panex, Paradise-XR, Pari, Panex. For more names, please click here.

Akathisia

In extreme cases, this can advance to a state known as akathisia – an intense emotional turmoil and physical restlessness that can be so unbearable as to trigger suicide in those who suffer from it.

Here is a link to an organization that is working in the area of medicine induced suicide risk, created by the family of the person who actually committed the suicide and in whose memory the lawsuit was fought and won by the family.

Okay, this blog post is not going to be longer than this. Time ensures brevity. However recently Glaxo SmithKline lost a lawsuit in the US, for the death of a man who took this medicine for a very short span of time. David Healy has written an elaborate post on the subject and he is also an expert on SSRIs. You are welcome to read his pPlaceholder Imageost here (or the top link where I posted it).

Towards the end of his post he recommends that the FDA should put a suicide warning on the Paxil drug. My post is just joining the dots together and in case you are on Paxil or any of its derivatives, please understand in case you feel more restless and agitated after taking the drug…it is probably a side effect of it, and if the doctor does not change the medicine- PLEASE CONSIDER CHANGING THE DOCTOR!

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